The first museum activities in Niğde started with the use of Akmedrese as a warehouse for the Istanbul Archaeological Museums during World War II. Afterward, with the establishment of the Niğde Museum in 1957, the Akmedrese was repaired and opened to visitors as the Niğde Museum after display and arrangement. The museum moved to its new building in 1977, and its first exhibition was held on November 20, 1982. The new display and arrangement in the museum were completed on 20 November 2001 upon the needs, and the museum was put into service again.
There are 6 exhibition halls in the Niğde Museum, where the archaeology of Central Anatolia is presented in chronological order.
1. HALL: The obsidian tools found in the Kaletepe Obsidian Workshop dated to the Paleolithic and Neolithic Periods and the Pınarbaşı Höyük, Köşk Höyük, and Tepecik Höyük excavations dated to the Neolithic Age, as well as the unique artifacts recovered from the Köşk Höyük excavations, which was the vital center of the Neolithic and Chalcolithic Age, and the "Köşk Höyük Chalcolithic House" is on display.
2. HALL: Göltepe Mound finds dating to the Old Bronze Age and the gallery entrance in the Kestel stannary opposite the mound are exhibited. In the second big showcase; the palace finds unearthed in the Acemhöyük (Puruşhanda) excavation, which was the important center of the Assyrian Trade Colonies Age, are exhibited.
3. HALL: Steles of the god of storm and fertility belonging to the late Hittite city-states Nahita and Tuvanuva, inscriptions written in Hittite hieroglyphs, finds from the Kaynarca Tumulus, Phrygian period ceramics and the "Lion of Göllüdağ" are exhibited.
4. HALL: It is divided into finds from the Hellenistic, Roman, and Byzantine Periods. In the hall; there are finds unearthed in the excavations of Tepebağları, Porsuk Höyük and Acemhöyük, sculptures, and statuettes from the Roman Period, and works from the Byzantine Period.
5. HALL: Coins and mummies are on display. A-Coin Section: Coin minting technique and general definitions, Greek, Hellenistic, Roman, Byzantine, and Islamic-Ottoman coins in chronological order, a silver treasure from the Seljuks and the Tepebağları treasure belonging to the Kingdom of Cappadocia. B-Mummy Section: The "Sister Mummy" found in Aksaray Ihlara Valley and 4 child mummies unearthed from the Çanlı Church are exhibited.
6. HALL: Weapons, manuscripts, writing sets, lighting tools, carpets, rugs, realms, jewelry, and a tray belonging to the Qajar Turks are exhibited in the hall, where the ethnographic culture of the region is on the verge of disappearing. In the hall, a dinner preparation theme was created in the Niğde house in the last century.